Hirudin/antistatin (IPR011061)
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| Link | https://www.ebi.ac.uk/interpro/entry/InterPro/IPR011061/ |
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| Type | App |
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| Dataset Raw |
Leeches, such as Hirudo medicinalis (Medicinal leech), produce a variety of antihaemostatic proteins that act as proteinase inhibitors. These inhibitors are used to aid the leech in feeding upon its host by blocking blood coagulation
. Examples of these proteins include hirustasin (inhibitor of tissue kallikrein, trypsin, alpha-chymotrypsin, and granulocyte cathepsin G)
, bdellastasin (inhibitor of trypsin, plasmin, and acrosin)
, factor Xa inhibitor antistasin (inhibitor of blood coagulation factor Xa)
, hirudin (thrombin inhibitor), decorsin (inhibitor of platelet aggregation)
and haemadin (thrombin inhibitor)
.